Rescuing mitochondrial motility

Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons

BACKGROUND The trafficking of mitochondria within neurons is a highly regulated process. In an earlier study, we found that serotonin (5-HT), acting through the 5-HT1A receptor subtype, promotes axonal transport of mitochondria in cultured hippocampal neurons by increasing Akt activity, and consequently decreasing glycogen synthase kinase (GSK3beta) activity. This finding suggests a critical ro...

Mitochondrial motility and vascular smooth muscle proliferation.

OBJECTIVE Mitochondria are widely described as being highly dynamic and adaptable organelles, and their movement is thought to be vital for cell function. Yet, in various native cells, including those of heart and smooth muscle, mitochondria are stationary and rigidly structured. The significance of the differences in mitochondrial behavior to the physiological function of cells is unclear and ...

The effect of aminoguanidine on sperm motility and mitochondrial membrane potential in varicocelized rats

Objective(s): Increased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicoceli...

Rescuing doctors in distress.

burnout or depression among physicians: financial cuts, relentless night shifts, long hours of work, overwhelming responsibility, dealing with life-threatening conditions, distress over the limitations of medical care, or just working conditions that have worsened in recent decades as a result of increasing time pressure, competition, explosion of knowledge, administrative loads or lack of auto...

Rescuing Frankfurt-Style Cases